Lux Capital Management, LLC - Oct 6, 2021 Form 3 Insider Report for Science 37 Holdings, Inc. (SNCE)

Role: 10%+ Owner
Signature: Lux Capital Management, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member
Stock symbol: SNCE
Transactions as of: Oct 6, 2021
Transactions value $: $0
Form type: 3
Date filed: 10/18/2021, 04:32 PM
Next filing: Apr 6, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	SNCE	Common Stock						11.7M	Oct 6, 2021	By Lux Ventures IV, L.P.	F1, F2, F3
holding	SNCE	Common Stock						3.51M	Oct 6, 2021	By Lux Co-Invest Opportunities, L.P.	F1, F2, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On October 6, 2021, pursuant to that certain Agreement and Plan of Merger, dated as of May 6, 2021, by and among the Issuer (f/k/a LifeSci Acquisition II Corp.), LifeSci Acquisition II Merger Sub, Inc., Inc. ("Merger Sub"), and Science 37, Inc. ("Legacy Science 37"), Merger Sub merged with and into Legacy Science 37, with Legacy Science 37 surviving as a wholly owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, each share of common stock of Legacy Science 37 was converted into the right to receive approximately 1.8153 shares of the Issuer's Common Stock.
F2	Lux Venture Partners IV, LLC is the general partner of Lux Ventures IV, L.P. and exercises voting and dispositive power over the shares held by Lux Ventures IV, L.P. Lux Co-Invest Partners, LLC is the general partner of Lux Co-Invest Opportunities, L.P. and exercises voting and dispositive power over the shares held by Lux Co-Invest Opportunities, L.P. Peter Hebert and Josh Wolfe are the sole managers of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC and may be deemed to share voting and dispositive power for the shares held by each of Lux Ventures IV, L.P. and Lux Co-Invest Opportunities, L.P. Lux Capital Management, LLC, as the investment manager for each of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC, may be deemed to share voting and investment powers for the shares held by each of Lux Ventures IV, L.P. and Lux Co-Invest Opportunities, L.P.
F3	Each of Lux Capital Management, LLC, Lux Venture Partners IV, LLC, Lux Co-Invest Partners, LLC, Peter Hebert and Josh Wolfe disclaim beneficial ownership over the shares reported herein except to the extent of their pecuniary interest therein.